GCN5 and E2F1 stimulate nucleotide excision repair by promoting H3K9 acetylation at sites of damage
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منابع مشابه
GCN5 and E2F1 stimulate nucleotide excision repair by promoting H3K9 acetylation at sites of damage
Chromatin structure is known to be a barrier to DNA repair and a large number of studies have now identified various factors that modify histones and remodel nucleosomes to facilitate repair. In response to ultraviolet (UV) radiation several histones are acetylated and this enhances the repair of DNA photoproducts by the nucleotide excision repair (NER) pathway. However, the molecular mechanism...
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Nucleotide excision repair (NER)l in all organisms, is able to accommodate to virtually any kind of DNA damage unlike many repair systems whose specificity is limited to a single species of damage. As a consequence NER has the advantage of being effective in responding to new types of environmental agents able to damage DNA. The model repair system under extensive study is the Escherichia coli ...
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As a blueprint for genetic information, the structural and functional integrity of DNA must be maintained during cell division and gamete formation. However, this fundamental principle is threatened continuously by the vulnerability of DNA itself and/or by assaults from endogenously produced agents, such as reactive oxygen species and other metabolites, as well as various environmental agents i...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 2010
ISSN: 1362-4962,0305-1048
DOI: 10.1093/nar/gkq983